Theses

Articles on GDNF and their receptors


GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function

Maritina Sergaki and Carlos F. Ibáñez (2017)
Cell Reports volume 18, Issue 2, p367–379
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Biology of GDNF and its receptors — Relevance for disorders of the central nervous system

Ibanez, C.F and Andressoo, J.-O. (2016)
Neurobiology of Diseasedoi:10.1016/j.nbd.2016.01.021
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Ibanez_CSHPB2013.jpg
Structure and Physiology of the RET Receptor Tyrosine Kinase
Ibanez, C.F (2013)
Cold Spring Harb. Perspect. Biol., 5:a009134
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Critical role of GFRa1 in the development and function of the main olfactory system
Marks, C., Belluscio, L. and Ibanez, C.F. (2012)
J. Neurosci., 32, 17306-17320
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MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFR
a1 and a new transmembrane receptor partner
Perrinjaquet, M., Sjostrand, S., Moliner, A., Zechel, S., Lamballe, F., Maina, F. and Ibanez, C.F. (2011)
J. Cell Sci. 124, 2797-2805
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Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase
Perrinjaquet, M., Vilar, M. and Ibanez, C.F. (2010)
J. Biol. Chem. 285, 31867-31875
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Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRa1 signaling
Canty, A.J., Dietze, J., Harvey, M., Enomoto, H., Milbrandt, J. and Ibanez, C.F. (2009)
J. Neurosci. 29, 10695-10705
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Catecholaminergic neuron survival: Getting hooked on GDNF
Ibanez, C.F. (2008)
Nat. Neurosci., 11, 735-736
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Insights into GFRa1 Regulation of Neural Cell Adhesion Molecule (NCAM) Function from Structure-Function Analysis of the NCAM/GFRa1 Receptor

Sjostrand and Ibanez, C.F. (2008)
J. Biol. Chem., 283, 13792 -13798
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Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion
Sjostrand, D., Carlsson, J., Paratcha, G,. Persson, B. and Ibanez, C.F. (2007)
J. Biol. Chem., 282, 12734-12740
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GDNF and GFRa1 promote formation of neuronal synapses by ligand-induced cell adhesion
Ledda, F., Paratcha, G., Sandoval-Guzman, T. and Ibanez, C.F. (2007)
Nat. Neurosci., 10, 293-300
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Self-association of the transmembrane domain of RET underlines oncogenic activation by MEN2A mutattions

Kjaer, S., Kurokawa, K., Perrinjaquet, M., Abrescia, C., and Ibanez, C.F. (2006)
Oncogene 25, 7086-7095
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GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream

Paratcha, G., Ibanez, C.F. and Ledda, F. (2006)
Mol. Cell. Neurosci., 31, 505-514
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Distinct turnover of alternatively-spliced isoforms of the Ret receptor tyrosine kinase mediated by differential recruitment of the Cbl ubiquitin ligase

Scott, R.P., Eketjall, S., Aineskog, H. and Ibanez, C.F. (2005)
J. Biol. Chem. 280, 13442-13449
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GDNF and GFRa1 promote differentiation and tangential migration of cortical GABAergic neurons

Pozas, E. and Ibanez, C.F. (2005)
Neuron, 45, 701-713
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Retrograde propagation of GDNF-mediated signals in sympathetic neurons

Coulpier, M. and Ibanez, C.F. (2004)
Mol. Cell. Neurosci., 27, 132-139
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Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET
Kjaer, S. and Ibanez, C.F. (2003)
Hum. Mol. Gen. 12, 2133-2144
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Identification of a Surface for Binding to the GDNF-GFRa1 Complex in the First Cadherin-like Domain of RET
Kjaer, S. and Ibanez, C.F. (2003)
J. Biol. Chem. 278, 47898-47904
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The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands
Paratcha, G., Ledda, F. and Ibanez, C.F. (2003)
Cell 113, 867-879
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Target-Derived GFRa1 as an Attractive Guidance Signal for Developing Sensory and Sympathetic Axons via Activation of Cdk5

Ledda, F., Paratcha, G., and Ibanez, C. F. (2002)
Neuron 36, 387-401
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Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease
Eketjall, S. and Ibanez, C.F. (2002)
Hum. Mol. Gen.11, 325-329
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Structure and chemical Inhibition of the RET tyrosine kinase domain
Knowless, P.P., Murray-Rust, J., Kjaer, S., Scott, R.P., Hanrahan, S., Santoro, M., Ibanez, C.F. and McDonald, N.Q. (2006)
J. Biol. Chem. 281, 33577-33587. [PDF]

Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells
Abrescia, C., Sjostrand, D., Kjaer, S. and Ibanez, C.F. (2005)
FEBS Lett. 579, 3789-3796. [PDF]

Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: Importance of tyrosine 1062 for GDNF-mediated neuronal differentiation and survival
Coulpier, M., Anders, J., and Ibanez, C. F. (2002)
J. Biol. Chem. 277, 1991-1999 [PDF]

Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site
Anders, J., Kjaer, S., and Ibanez, C. F. (2001)
J. Biol. Chem. 276, 35806-35817. [PDF]

Determinants of ligand binding specificity in the GDNF family receptor alphas (GFRÅ’±s)
Scott, R. P., and Ibanez, C. F. (2001)
J. Biol. Chem. 276, 1450-1458. [PDF]

Released GFR alpha 1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
Paratcha, G., Ledda, F., Baars, L., Coulpier, M., Besset, V., Anders, J., Scott, R., and Ibanez, C. F. (2001)
Neuron 29, 171-184 [PDF]

Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase
Besset, V., Scott, R. P., and Ibanez, C. F. (2000)
J. Biol. Chem. 275, 39159-39166. [PDF]

Mammalian GFRa4, a divergent member of the GFRa family of coreceptors for GDNF family ligands, is a receptor for the neurotrophic factor persephin
Masure, S., Cik, M., Hoefnagel, E., Nosrat, C. A., van Der Linden, I., Scott, R., Van Gompel, P., Lesage, A. S., Verhasselt, P., Ibanez, C. F., and Gordon, R. D. (2000)
J. Biol. Chem. 275, 39427-39434 [PDF]

Distinct structure elements in GDNF mediate binding to GFR alpha 1 and activation of the GFR alpha 1-c-Ret receptor complex
Eketjall, S., Fainzilber, M., Murray-Rust, J., and Ibanez, C. F. (1999)
EMBO J. 18, 5901-5910. [PDF]

Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells
Trupp, M., Scott, R., Whittemore, S. R., and Ibanez, C. F. (1999)
J. Biol. Chem. 274, 20885-20894 [PDF]

Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase
Trupp, M., Raynoschek, C., Belluardo, N., and Ibanez, C. F. (1998)
Mol. Cell. Neurosci. 11, 47-63 [PDF]

Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. F. (1997)
J. Neurosci. 17, 3554-3567 [PDF]

Functional receptor for glial cell line-derived neurotrophic factor encoded by the c-ret proto-oncogene product
Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C. F. (1996)
Nature 381, 785-789 [PDF]

GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
Arenas, E., Trupp, M., Akerud, P., and Ibanez, C. F. (1995)
Neuron 15, 1465-1473 [PDF]

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
Trupp, M., Ryden, M., Jornvall, H., Timmusk, T., Funakoshi, H., Arenas, E., and Ibanez, C. F. (1995)
J. Cell Biol. 130, 137-148 [PDF]