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PKC-mediated RhoGDI interaction with p75NTR JUX domain

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RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75 NTR to gate axon growth and neuron survival

Ajeena Ramanujan , Zhen Li, Yanchen Ma, Zhi Lin & Carlos F. Ibáñez (2024)
EMBO Reports doi.org/10.1038/s44319-024-00064-2

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Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization

Favio A Krapacher , Diana Fernandez-Suarez, Annika Andersson , Alvaro Carrier-Ruiz & Carlos F. Ibáñez (2021)
The EMBO Journal (2022) e110721

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Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function

Diana Fernández-Suárez , Favio A. Krapacher, Katarzyna Pietrajtis, Annika Andersson, Lilian Kisiswa, Alvaro Carrier-Ruiz, Marco A. Diana and Carlos F. Ibáñez (2021)
PLOS Biology (2021), vol 19(11): e3001350

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ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons

Christina Göngrich, Favio Krapacher, Hermany Munguba, Diana Fernández-Suárez, Annika Andersson, Jens Hjerling-Leffler  and Carlos F. Ibáñez (2019)
Journal of Cell Biology (2019) DOI: 10.1083/jcb.201905002

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Cell Death and Disease, doi:10.1038/s41419-019-1970-x


MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating  granule layer/white matter boundary

Diana Fernández-Suárez, Favio A. Krapacher, Annika Andersson, Carlos F. Ibáñez and Lilian Kisiswa (2019)
Cell Death and Disease (2019)10:732

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The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation

Lik-Wei Wong, Jason Y. Tann, Carlos F. Ibanez, and Sajikumar Sreedharan (2019)
J. Neurosci. 2019 • 39(28):5452–5465

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Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing

Jason Y Tann, Lik‐Wei Wong, Sreedharan Sajikumar, and Carlos F. Ibáñez (2019)
The EMBO Journal (2019) 10.15252/embj.2018100989

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A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth

Eddy T. H. Goh, Zhi Lin, Bo Young Ahn, Vanessa Lopes-Rodrigues, Ngoc Ha Dang, Shuhailah Salim, Bryan Berger, Brian Dymock, Donna L. Senger and Carlos F. Ibáñez (2018)
Cell Chemical Biology (2018), 25, 1485–1494

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Download supplemental information HERE


RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival

Lilian Kisiswa, Diana Fernandez-Suarez, Maria Christina Sergaki and Carlos F. Ibáñez (2018)
Cell Reports Volume 24, Issue 4, p1013–1024, 24 July 2018

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Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons

Sabrina Zechel, Diana Fernandez-Suarez and Carlos F. Ibáñez (2018)

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Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning

Maritina Sergaki, JC Lopez-Ramos, S Stagkourakis, A Gruart, C Broberger, JM Delgado-García and Carlos F. Ibáñez (2017)
Cell Reports volume 19, Issue 10, p1977-1986
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GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function

Maritina Sergaki and Carlos F. Ibáñez (2017)
Cell Reports volume 18, Issue 2, p367–379
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Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons

Sabrina Zechel, Yasushi Nakagawa and Carlos F. Ibáñez (2016)
eLife 2016;5:e20770
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(Supplemental information 31.6MB)

Tanaka_JNeurosci2016
Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS

Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim and Carlos F. Ibáñez (2016)
J Neurosci 2016, 36, 5587
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Neuron-type-specific signaling by the p75NTR death receptor regulated by differential proteolytic cleavage
Annalisa Vicario, Lilian Kisiswa, Jason Y. Tann, Claire E. Kelly and Carlos F. Ibanez (2015)
J. Cell Sci. 2015, 128, 1507-1517
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Genetic Dissection of Neurotrophin Signaling through the p75 Neu
Genetic dissection of neurotrophin signaling through the p75 neurotrophin  receptor
Charalampopoulos, I, Vicario, A, Pediaditakis, I ,Gravanis, A, Simi, A and Ibanez, CF  (2012)
Cell Reports, 10.1016/j.celrep.2012.11.009
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Critical role of GFRa1 in the development and function of the main olfactory system
Marks, C., Belluscio, L. and Ibanez, C.F. (2012)
J. Neurosci., 32, 17306-17320
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p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity
Ibanez, C.F. and Simi, A. (2012)
Trends Neurosci., 35, 431–440
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MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFR
a1 and a new transmembrane receptor partner
Perrinjaquet, M., Sjostrand, S., Moliner, A., Zechel, S., Lamballe, F., Maina, F. and Ibanez, C.F. (2011)
J. Cell Sci. 124, 2797-2805
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Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRa1 signaling
Canty, A.J., Dietze, J., Harvey, M., Enomoto, H., Milbrandt, J. and Ibanez, C.F. (2009)
J. Neurosci. 29, 10695-10705
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Ligand-independent signaling by disulfide- crosslinked dimers of the p75 neurotrophin receptor
Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Reversi, A., Klos-Applequist, J., Karaca, E., Simi, A., Spuch, C., Choi, S., Friedman, W.J., Ericson, J., Schiavo, G., Carter, B.D. and Ibanez, C.F. (2009)
J. Cell Sci, 122, 3351-3357
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Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers
Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Simi, A., Karaca, E., Reversi, A., Choi, S., Bothwell, M., Mingarro, I., Friedman, W.J., Schiavo, G., Bastiaens, P.I.H., Verveer, P.J., Carter, B.D. and Ibanez, C.F. (2009)
Neuron, 62, 72-83
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Catecholaminergic neuron survival: Getting hooked on GDNF
Ibanez, C.F. (2008)
Nat. Neurosci., 11, 735-736
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Insights into GFRa1 Regulation of Neural Cell Adhesion Molecule (NCAM) Function from Structure-Function Analysis of the NCAM/GFRa1 Receptor

Sjostrand and Ibanez, C.F. (2008)
J. Biol. Chem., 283, 13792 -13798
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Disruption of EphA/ephrin-A signaling in the nigro-striatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine

Sieber, B.-A., Kuzmin, A., Canals, J.M., Danielsson, A., Paratcha, G., Arenas, E., Alberch, J., Ogren, S.O. and Ibanez, C.F. (2004)
Mol. Cell. Neurosci., 26, 418-428. [PDF]


Jekyll-Hyde neurotrophins: the story of proNGF
Ibanez, C.F. (2002)
Trends Neurosci, 25, 284-286
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