Theses

Mikael Ryden


“Neurotrophic factors and their receptors: Structure-function relationships and signalling mechanisms”
25 April, 1997

Abstract from KI website

External examiner:
Carl-Henrik Heldin
Ludwig Institute for Cancer Research
Uppsala, Sweden

This thesis is based on the following papers:

I. Ryden, M., Murray-Rust, J., Glass, D., Ilag, L.L., Trupp, M., Yancopoulos, G.D., McDonald, N.Q. and Ibanez, C.F. (1995) Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling. EMBO J., 14, 1979-1990. [PDF]

II. Ryden, M. and Ibanez, C.F. (1996) Binding of neurotrophin-3 to p75LNGFR, TrkA and TrkB mediated by a single functional epitope distinct from that recognized by TrkC. J. Biol. Chem., 271, 5623-5637 [PDF]

III. Ryden, M., Hempstead, B. and Ibanez, C.F. (1997) Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor. Manuscript. Later published in 1997, J. Bio.l Chem., 272, 16322-16328 [PDF]

IV. Ryden, M. and Ibanez, C.F. (1997) A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in NGF. Manuscript. Later published in 1997, J. Bio.l Chem., 272, 33085-33091 [PDF]

V. Ryden, M., Sehgal, R., Dominici, C., Schilling, F.H., Ibanez, C.F., Kogner, P. (1996) Br. J. Cancer 74, 773-779 [PubMed]

VI. Ryden, R., Imamura, T., Jornvall, H., Neveu, I., Trupp, M., Belluardo, N., Okadome, T., ten Dijke, P., and Ibanez, C. F. (1996). A novel type I serine-threonine kinase receptor predominantly expressed in the adult central nervous system. J. Biol. Chem. 271, 30603-30609 [PDF]

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