Theses

Leopold Ilag


“Biochemical and biophysical aspects of molecular recognition and signalling by neurotrophins”
7 November, 1997

Abstract from KI website

External examiner:
Ralph Bradshaw
University of California Irvine
Irvine, USA

This thesis is based on the following papers:

I. Ilag, L.L., Lonnerberg, P. Persson, H. and Ibanez, C.F. (1994) Role of a variable b-hairpin loop in determining biological specificities in neurotrophin family. J. Biol. Chem. 269: 19941-19946. [PDF]

II. Ibanez, C.F., Ilag, L.L., Murray-Rust, J. and Persson, H. (1993) An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin. EMBO J. 12: 2281-2293. [PDF]

III. Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N., Ryan, T., Acheson, A., Lindsay, R., Persson, H., Yancopoulos, G.D., DiStefano, P., and Ibanez, C.F. (1995) Pan-neurotrophin 1: A genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Proc. Natl. Acad. Sci. USA 92:607-611. [PDF]

IV. Ilag, L.L. and Ibanez, C.F. (1997) Engineering of the heparin-binding domain of neurotrophin-6 onto nerve growth factor. Manuscript. [HTML]

V. Liepinsh, E., Ilag, L.L., Otting, G., and Ibanez, C.F. (1997) NMR structure of the death domain of the p75 neurotrophin receptor. EMBO J. 16: 4999-5005. [PDF]

VI. Ilag, L.L., Rottenberger, C., Liepinsh, E., Ibanez, C.F., Otting, G., and Ilag, L.L. (1997) Selection of a peptide-ligand to the p75 neurotrophin receptor death domain and determination of its binding site by NMR. Manuscript. Later published in 1999 in Biochem. Biophys. Res. Comm.255, 104-109. [PDF]

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