Susanna Eketjall

“Structure function studies of GDNF and other members of the TGF-b superfamily”
12 November, 2002

Abstract from KI website

External examiner:
Mart Saarma
University of Helsinki
Helsinki, Finland

This thesis is based on the following papers:

I. Eketjall, S., Fainzilber, M., Murray-Rust, J., and Ibanez, C.F. (1999) Distinct structural elements in GDNF mediate binding to the GFRa1 and activation of the GFRa1-c-Ret receptor complex. EMBO J. 18, 5901-5910. [PDF]

II. Eketjall, S. and Ibanez C.F. (2002) Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease.Hum. Mol. Gen. 11, 325-329. [PDF]

III. Scott, R.P., Eketjall, S., Aineskog, H., and Ibanez, C.F. (2002) Distinct signaling mechanisms by isoforms of the Ret kinase receptor are mediated through differential interaction with Cbl and CrkL. Manuscript. Later published in 2005, J. Biol. Chem.: in press. [PDF]

IV. Eketjall, S., Jornvall, H., Lonnerberg, P., Kobayashi, S., and Ibanez, C.F. (2002) Recent Evolutionary Origin within the Primate Lineage of two Genes with Similarity to Members of the TGF-b Superfamily Specifically Expressed in the Nervous System. Manuscript. Later published in 2004: Cell. Mol. Life Sci., 61, 488-496. [PDF]

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