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Adult function of GFRα1 in medial habenula neurons


Thomas Ringstedt

“Neurothrophins during development : Overexpression in neural stem cells”
5 June, 1998

Abstract from KI website

External examiner:
Gary R. Lewin
Max-Delbruck Center for Molecular Medicine
Berlin, Germany

This thesis is based on the following papers:

I. Ringstedt, T., Lagercrantz, H., Persson, H. (1993) Expression of members of the trk family in the developing postnatal rat brain. Dev. Brain Res. 72, 119-131. [PubMed]

II. Ringstedt, T., Linnarsson, S., Wagner, J., Lendahl, U., Kokaia, Z., Arenas, E., Ernfors, P., and Ibanez, C. F. (1998). BDNF regulates reelin expression and cajal-retzius cell development in the cerebral cortex. Manuscript. Later published in 1998, Neuron 21, 305-315. [PDF]

III. Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P., and Ibanez, C. F. (1997). Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system. Development 124, 2603-2613. [PDF]

IV. Ringstedt, T., Ibanez, C. F., and Nosrat, C. (1998). Role of BDNF in target invasion in the gustatory system. Manuscript. Later published in 1999, J. Neurosci. 19, 3507-3518. [PDF]

V. Ringstedt, T., Tang, L.Q., Persson, H., Lendahl, U., Lagercrantz, H. (1995) Expression of c-fos, tyrosine hydroxylase, and neuropeptide mRNA in the rat brain around birth: effects of hypoxia and hypothermia. Pediatr Res. 1995 Jan;37(1):15-20. [PubMed]

Miles Trupp

“Neurotrophic signalling by GDNF and its receptors”
2 June, 1998

Abstract from KI website

External examiner:
Michael E. Greenberg
Harvard Medical School
Cambridge, USA

This thesis is based on the following papers:

I. Trupp, M., Ryden, M., Jornvall, H., Timmusk, T., Funakoshi, H., Arenas, E., and Ibanez, C. F. (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell. Biol. 130, 137-148 [PDF]

II. Arenas, E., Trupp, M., Akerud, P., and Ibanez, C. F. (1995). GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15, 1465-1473 [PDF]

III. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C. F. (1996). Functional receptor for glial cell line-derived neurotrophic factor encoded by the c-ret proto-oncogene product. Nature 381, 785-789 [PDF]

IV. Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. F. (1997). Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17, 3554-3567 [PDF]

V. Trupp, M., Raynoschek, C., Belluardo, N., and Ibanez, C. F. (1998). Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Mol. Cell. Neurosci. 11, 47-63 [PDF]

VI. Trupp, M., Scott, R., Whittemore, S. R., and Ibanez, C. F. (1998). Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells. Manuscript. Later published in 1999, J. Biol. Chem. 274, 20885-20894 [PDF]