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Adult function of GFRα1 in medial habenula neurons

Theses

Susanna Eketjall


“Structure function studies of GDNF and other members of the TGF-b superfamily”
12 November, 2002

Abstract from KI website

External examiner:
Mart Saarma
University of Helsinki
Helsinki, Finland

This thesis is based on the following papers:

I. Eketjall, S., Fainzilber, M., Murray-Rust, J., and Ibanez, C.F. (1999) Distinct structural elements in GDNF mediate binding to the GFRa1 and activation of the GFRa1-c-Ret receptor complex. EMBO J. 18, 5901-5910. [PDF]

II. Eketjall, S. and Ibanez C.F. (2002) Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease.Hum. Mol. Gen. 11, 325-329. [PDF]

III. Scott, R.P., Eketjall, S., Aineskog, H., and Ibanez, C.F. (2002) Distinct signaling mechanisms by isoforms of the Ret kinase receptor are mediated through differential interaction with Cbl and CrkL. Manuscript. Later published in 2005, J. Biol. Chem.: in press. [PDF]

IV. Eketjall, S., Jornvall, H., Lonnerberg, P., Kobayashi, S., and Ibanez, C.F. (2002) Recent Evolutionary Origin within the Primate Lineage of two Genes with Similarity to Members of the TGF-b Superfamily Specifically Expressed in the Nervous System. Manuscript. Later published in 2004: Cell. Mol. Life Sci., 61, 488-496. [PDF]

Rizaldy Scott


“Signal transduction mechanisms mediated by the GDNF family of ligands and their receptors”
8 November, 2002

External examiner:
Marc Billaud
Universite Claude Bernard Lyon 1
Lyon, France

This thesis is based on the following papers:

I. Scott, R. P. and Ibanez, C. F. (2001) Determinants of ligand binding specificity in the GDNF family receptor alphas (GFRas). J. Biol. Chem.276, 1450-1458. [PDF]

II. Scott, R. P., Cederlund, E., Bergmann and Ibanez, C. F. (2002) Structural characterization of GFRas: Identification of ligand binding epitopes, and mapping of disulfide bridges and glycosylation sites. Manuscript. [PDF]

III. Trupp, M.*, Scott, R. P.*, Whittemore, S. R., and Ibanez, C. F. (1999) Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells. J. Biol. Chem. 274, 20885-20894. *Shared first authorship. [PDF]

IV. Besset, V., Scott, R. P. and Ibanez, C. F. (2000). Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase. J. Biol. Chem. 275, 39159-39166. [PDF]

V. Scott, R.P., Eketjall, S., Aineskog, H. and Ibanez, C.F. (2002) Distinct signaling mechanisms by isoforms of the Ret kinase receptor are mediated through differential interaction with Cbl and CrkL. Manuscript. Later published in 2005: J. Biol. Chem.280, 13442-13449. [PDF]

VI. Scott, R. P., Murray-Rust, J., McDonald, N. and Ibanez, C. F. (2002) Production, purification, crystallization of the kinase domain of c-Ret and its oncogenic variants. Manuscript.