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Adult function of GFRα1 in medial habenula neurons


Lab Xmas Dinner 2010 documented for posterity

This year, our lab Xmas dinner took place at a Greek restaurant, to the acclaim of Greek and non-Greek lab members alike. Secret Santa was particularly generous this time. And some sipporo helped loosen up the dancers. Who could they have been? Find out HERE.

Maurice Perrinjaquet

“Control of neuronal survival, migration and outgrowth by GDNF and its receptors”
16 December, 2010

Abstract from KI website

External examiner:
Rosalind Segal
Departments of Neurobiology, Cancer Biology and Pediatric Oncology
Harvard Medical School and Dana-Farber Cancer Institute
Boston, MA, USA

This thesis is based on the following papers:

I. Perrinjaquet, M., Vilar, M. and Ibanez, C.F. (2010) Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J. Biol. Chem. 285, 31867-31875. [PDF]

II. Perrinjaquet, M., Sjostrand, D., Moliner, A., Zechel, S., Lambelle, F., Maina, F. and Ibanez, C.F. (2010). Met signaling in GABAergic neurons of the medial ganglionic eminence restricts GDNF activities in cells expressing GFRa1 and a novel transmembrane receptor. Manuscript. Later published in 2011: J. Cell Sci., 124, 2797-2805. [PDF]

III. Kjaer, S., Kurokawa, K., Perrinjaquet, M., Abrescia, C., and Ibanez, C.F. (2006) Self-association of the transmembrane domain of RET underlines oncogenic activation by MEN2A mutattions. Oncogene 25, 7086-7095. [PDF]

Sabbatical in Singapore

Carlos Ibanez and Annalena Moliner are heading to Singapore on December 18 for a 5-month sabbatical until May 2011. They will be hosted by Dr. Bing Lim of the Genome Institute of Singapore and Dr. Sai Kiang Lim of the Institute of Medical Biology, located at the Biopolis campus run by the Agency for Science, Technology and Research (A*STAR), Singapore’s lead government agency dedicated to fostering world-class scientific research. They will be working on several of our ongoing collaborative projects with these groups, applying advanced functional genomics and stem cell biology methods to study pancreatic islet development and function in cells and tissue derived from mouse mutants generated at the laboratory.

Lab Xmas Dinner 2010

Restaurant Greken pa Hornet
December 6, 2010

Some sipporo helped the dancers loosen up.
Click on thumbnail for more images.