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RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75 NTR to gate axon growth and neuron survival

Ajeena Ramanujan , Zhen Li, Yanchen Ma, Zhi Lin & Carlos F. Ibáñez (2024)
EMBO Reports doi.org/10.1038/s44319-024-00064-2

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Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization

Chenju Yi1, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez (2020)
The EMBO Journal (2020) e104450

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ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons

Christina Göngrich, Favio Krapacher, Hermany Munguba, Diana Fernández-Suárez, Annika Andersson, Jens Hjerling-Leffler  and Carlos F. Ibáñez (2019)

Journal of Cell Biology (2019) DOI: 10.1083/jcb.201905002

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Cell Death and Disease, doi:10.1038/s41419-019-1970-x


MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating  granule layer/white matter boundary

Diana Fernández-Suárez, Favio A. Krapacher, Annika Andersson, Carlos F. Ibáñez and Lilian Kisiswa (2019)

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The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation

Lik-Wei Wong, Jason Y. Tann, Carlos F. Ibanez, and Sajikumar Sreedharan (2019)

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Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing

Jason Y Tann, Lik‐Wei Wong, Sreedharan Sajikumar, and Carlos F. Ibáñez (2019)
The EMBO Journal (2019) 10.15252/embj.2018100989

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A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth

Eddy T. H. Goh, Zhi Lin, Bo Young Ahn, Vanessa Lopes-Rodrigues, Ngoc Ha Dang, Shuhailah Salim, Bryan Berger, Brian Dymock, Donna L. Senger and Carlos F. Ibáñez (2018)
Cell Chemical Biology (2018) 25, 1485–1494

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