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PKC-mediated RhoGDI interaction with p75NTR JUX domain

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Singapore media highlights identification of small molecule targeting the transmembrane domain of death receptor p75NTR

The Saturday edition of the The Straits Times publishes today an interview with Carlos Ibanez highlighting the identification a small molecule targeting the transmembrane domain of death receptor p75NTR that induces melanoma cell death and reduces tumor growth (reported in our paper published in Cell Chemical Biology). Read the full article here. Also newspaper Lianhe Zaobao (Chinese Daily) carried a story (in Chinese) on the discovery.

Special award from Cancerfonden to Carlos Ibanez lab for work on small molecules targeting p75NTR in cancer

Cancerfonden, the largest research funding charity organization in Sweden, today decided to award a special grant to Carlos Ibanez lab for drug discovery efforts targeting the p75 neurotrophin receptor in melanoma and glioma, based on our pilot study recently published in Cell Chemical Biology.