Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function
Diana Fernández-Suárez , Favio A. Krapacher, Katarzyna Pietrajtis, Annika Andersson, Lilian Kisiswa, Alvaro Carrier-Ruiz, Marco A. Diana and Carlos F. Ibáñez (2021) PLOS Biology (2021), vol 19(11): e3001350
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Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7
Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization
Chenju Yi1, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez (2020) The EMBO Journal (2020) e104450
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Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7
Patricia Marmol-Carrasco, Favio Krapacher and Carlos F. Ibáñez (2020) eLife 2020;9:e54721
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CD137 negatively affects “browning” of white adipose tissue during cold exposure
Rajkamal Srivastava, Annalena Moliner, Ee-Soo Lee, Emily Nickles, Eunice Sim, Chang Liu, Herbert Schwarz and Carlos F. Ibáñez (2020) J. Biol. Chem. (2020) 295(7) 2034 –2042
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ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons
Cell Death and Disease, doi:10.1038/s41419-019-1970-x
MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary
Diana Fernández-Suárez, Favio A. Krapacher, Annika Andersson, Carlos F. Ibáñez and Lilian Kisiswa (2019) Cell Death and Disease (2019)10:732
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The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation
A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth
Eddy T. H. Goh, Zhi Lin, Bo Young Ahn, Vanessa Lopes-Rodrigues, Ngoc Ha Dang, Shuhailah Salim, Bryan Berger, Brian Dymock, Donna L. Senger and Carlos F. Ibáñez (2018) Cell Chemical Biology (2018), 25, 1485–1494
Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
Sabrina Zechel, Diana Fernandez-Suarez and Carlos F. Ibáñez (2018) Biology Open 2018 7: bio033753
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Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning
Maritina Sergaki, JC Lopez-Ramos, S Stagkourakis, A Gruart, C Broberger, JM Delgado-García and Carlos F. Ibáñez (2017) Cell Reports volume 19, Issue 10, p1977-1986
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GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function
Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons
Sabrina Zechel, Yasushi Nakagawa and Carlos F. Ibáñez (2016) eLife 2016;5:e20770
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(Supplemental information 31.6MB)
Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS
Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim and Carlos F. Ibáñez (2016) J Neurosci 2016, 36, 5587
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Structural basis of death domain signaling in the p75 neurotrophin receptor
Zhi Lin, Jason Y. Tann, Eddy T. H. Goh, Claire Kelly, Kim Buay Lim, Jianfang Gao and Carlos F. Ibáñez (2015) eLife 2015;10.7554/eLife.11692 Click on thumbnail to display PDF
Neuron-type-specific signaling by the p75NTR death receptor regulated by differential proteolytic cleavage Annalisa Vicario, Lilian Kisiswa, Jason Y. Tann, Claire E. Kelly and Carlos F. Ibanez (2015) J. Cell Sci. 2015, 128, 1507-1517 Click on thumbnail to display PDF
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially-resolved RNA-seq
Sabrina Zechel, Pawel Zajac, Peter Lonnerberg, Carlos F Ibanez and Sten Linnarsson (2014) Genome Biology, 15:486-497
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Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity
Tingqing Guo, Patricia Marmol, Annalena Moliner, Marie Björnholm, Chao Zhang, Kevan M Shokat and Carlos F Ibanez (2013) eLife 2014;3:e03245
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Differential regulation of pancreatic islet insulin secretion and Smad proteins by activin ligands
Wu, H., Mezghenna, K., Marmol, P., Guo, T., Moliner, A., Yang, S.N, Berggren, P.O. and Ibanez, C.F. (2014) Diabetologia, 57: 148–156.
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Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor Charalampopoulos, I, Vicario, A, Pediaditakis, I ,Gravanis, A, Simi, A and Ibanez, CF (2012) Cell Reports, 10.1016/j.celrep.2012.11.009
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Critical role of GFRa1 in the development and function of the main olfactory system Marks, C., Belluscio, L. and Ibanez, C.F. (2012) J. Neurosci., 32, 17306-17320
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Neuroendocrine control of female reproductive function by the activin receptor ALK7 Sandoval-Guzman, T., Göngrich, C., Moliner, A., Guo, T., Wu, H., Broberger, C. and Ibanez, C.F. (2012) FASEB Journal, 26:4966-4976
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MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFRa1 and a new transmembrane receptor partner Perrinjaquet, M., Sjostrand, S., Moliner, A., Zechel, S., Lamballe, F., Maina, F. and Ibanez, C.F. (2011) J. Cell Sci. 124, 2797-2805
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Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase Perrinjaquet, M., Vilar, M. and Ibanez, C.F. (2010) J. Biol. Chem. 285, 31867-31875
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Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRa1 signaling Canty, A.J., Dietze, J., Harvey, M., Enomoto, H., Milbrandt, J. and Ibanez, C.F. (2009) J. Neurosci. 29, 10695-10705
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Ligand-independent signaling by disulfide- crosslinked dimers of the p75 neurotrophin receptor Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Reversi, A., Klos-Applequist, J., Karaca, E., Simi, A., Spuch, C., Choi, S., Friedman, W.J., Ericson, J., Schiavo, G., Carter, B.D. and Ibanez, C.F. (2009) J. Cell Sci, 122, 3351-3357
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Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Simi, A., Karaca, E., Reversi, A., Choi, S., Bothwell, M., Mingarro, I., Friedman, W.J., Schiavo, G., Bastiaens, P.I.H., Verveer, P.J., Carter, B.D. and Ibanez, C.F. (2009) Neuron, 62, 72-83
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Insights into GFRa1 Regulation of Neural Cell Adhesion Molecule (NCAM) Function from Structure-Function Analysis of the NCAM/GFRa1 Receptor
Sjostrand and Ibanez, C.F. (2008) J. Biol. Chem., 283, 13792 -13798
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Growth/Differentiation Factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity Andersson, O., Korach-Andre, M., Reissmann, E., Ibanez, C.F. (corresp. author) and Bertolino, P. (2008) Proc. Natl. Acad. USA, 105, 7252-7256
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Activin B receptor ALK7 is a negative regulator of pancreatic b-cell function Bertolino, P., Nilsson, R., Reissmann, E., Andersson, O., Berggren, P.-O. and Ibanez, C.F. (2008) Proc. Natl. Acad. USA, 105, 7246-7251
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Mouse embryonic stem cell-derived spheres with distinct neurogenic potentials
Moliner, A., Ernfors, P., Ibanez, C.F. (ca) and Andang, M. (2008) Stem Cells & Dev., 17, 233-243
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Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation Andang, M., Hjerling-Leffler, J., Moliner, A., Lundgren, T.K., Castelo-Branco, G., Nanou, E., Pozas, E., Bryja, V., Halliez, S., Nishimaru, H., Wilbertz, J., Arenas, E., Koltzenburg, M., Charnay, P., El Manira, A., Ibanez, C.F. and Ernfors, P. (2008) Nature, 451, 460-464 [PDF]
Optimized mouse ES cell culture system by suspension growth in a fully defined medium Andang, M., Moliner, A., Ibanez, C.F. and Ernfors, P. (2008) Nat. Protocols, 3, 1-5 [PDF]
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
Andersson, O., Bertolino, P. and Ibanez, C.F. (2007) Dev. Biol., 311, 500-511
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Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion Sjostrand, D., Carlsson, J., Paratcha, G,. Persson, B. and Ibanez, C.F. (2007) J. Biol. Chem., 282, 12734-12740
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GDNF and GFRa1 promote formation of neuronal synapses by ligand-induced cell adhesion Ledda, F., Paratcha, G., Sandoval-Guzman, T. and Ibanez, C.F. (2007) Nat. Neurosci., 10, 293-300
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Growth differentiation factor 11 signals through the transforming growth factor beta receptor ALK5 to regionalize the anterior-posterior axis
Andersson, O., Reissmann, E. and Ibanez, C.F. (2006) EMBO Rep., 7, 831-837
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Self-association of the transmembrane domain of RET underlines oncogenic activation by MEN2A mutattions
Kjaer, S., Kurokawa, K., Perrinjaquet, M., Abrescia, C., and Ibanez, C.F. (2006) Oncogene 25, 7086-7095
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Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle Vilar, V. Murillo-Carretero, M., Mira, H., Magnusson, K., Besset, V. and Ibanez, C.F. (2006) EMBO J., 25, 1219-1230
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Synergistic interaction between Gdf1 and Nodal during anterior axis development
Andersson, O., Reissmann, E., Jornvall, H. and Ibanez, C.F. (2006) Dev. Biol., 293, 370-381
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GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream
Paratcha, G., Ibanez, C.F. and Ledda, F. (2006) Mol. Cell. Neurosci., 31, 505-514
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Distinct turnover of alternatively-spliced isoforms of the Ret receptor tyrosine kinase mediated by differential recruitment of the Cbl ubiquitin ligase
Scott, R.P., Eketjall, S., Aineskog, H. and Ibanez, C.F. (2005) J. Biol. Chem. 280, 13442-13449
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GDNF and GFRa1 promote differentiation and tangential migration of cortical GABAergic neurons
Pozas, E. and Ibanez, C.F. (2005) Neuron, 45, 701-713
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ALK7, a receptor for Nodal, is dispensable for embryogenesis and left-right patterning in the mouse Jornvall, H., Reissmann, E., Andersson, O., Mehrkash, M. and Ibanez, C.F. (2004) Mol. Cell. Biol., 24, 9383-9389
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Retrograde propagation of GDNF-mediated signals in sympathetic neurons
Coulpier, M. and Ibanez, C.F. (2004) Mol. Cell. Neurosci., 27, 132-139
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Disruption of EphA/ephrin-A signaling in the nigro-striatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine
Sieber, B.-A., Kuzmin, A., Canals, J.M., Danielsson, A., Paratcha, G., Arenas, E., Alberch, J., Ogren, S.O. and Ibanez, C.F. (2004) Mol. Cell. Neurosci., 26, 418-428. [PDF]
Recent evolutionary origin within the primate lineage of two pseudogenes with similarity to members of the TGF-b superfamily
Eketjall, E., Jornvall, H., Lonnerberg, P., Kobayashi, S. and Ibanez, C.F. (2004) Cell. Mol. Life Sci., 61, 488-496
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Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET Kjaer, S. and Ibanez, C.F. (2003) Hum. Mol. Gen. 12, 2133-2144
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Cross-talk between the Notch and TGF-b signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
Blokzijl, A., Dahlqvist, C., Reissmann, E., Falk, A., Moliner, A., Lendahl, U. and Ibanez, C. F. (2003) J. Cell Biol. 163, 723-728
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Identification of a Surface for Binding to the GDNF-GFRa1 Complex in the First Cadherin-like Domain of RET Kjaer, S. and Ibanez, C.F. (2003) J. Biol. Chem. 278, 47898-47904
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The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands Paratcha, G., Ledda, F. and Ibanez, C.F. (2003) Cell 113, 867-879
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Target-Derived GFRa1 as an Attractive Guidance Signal for Developing Sensory and Sympathetic Axons via Activation of Cdk5
Ledda, F., Paratcha, G., and Ibanez, C. F. (2002) Neuron 36, 387-401
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Functional characterization of mutations in the GDNF gene of patients with Hirschsprung disease Eketjall, S. and Ibanez, C.F. (2002) Hum. Mol. Gen.11, 325-329
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Structure and chemical Inhibition of the RET tyrosine kinase domain Knowless, P.P., Murray-Rust, J., Kjaer, S., Scott, R.P., Hanrahan, S., Santoro, M., Ibanez, C.F. and McDonald, N.Q. (2006) J. Biol. Chem. 281, 33577-33587. [PDF]
Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells
Abrescia, C., Sjostrand, D., Kjaer, S. and Ibanez, C.F. (2005) FEBS Lett. 579, 3789-3796. [PDF]
Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: Importance of tyrosine 1062 for GDNF-mediated neuronal differentiation and survival
Coulpier, M., Anders, J., and Ibanez, C. F. (2002) J. Biol. Chem. 277, 1991-1999 [PDF]
Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site
Anders, J., Kjaer, S., and Ibanez, C. F. (2001) J. Biol. Chem. 276, 35806-35817. [PDF]
Determinants of ligand binding specificity in the GDNF family receptor alphas (GFRÅ’±s) Scott, R. P., and Ibanez, C. F. (2001) J. Biol. Chem. 276, 1450-1458. [PDF]
Released GFR alpha 1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts Paratcha, G., Ledda, F., Baars, L., Coulpier, M., Besset, V., Anders, J., Scott, R., and Ibanez, C. F. (2001) Neuron 29, 171-184 [PDF]
Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase Besset, V., Scott, R. P., and Ibanez, C. F. (2000) J. Biol. Chem. 275, 39159-39166. [PDF]
Mammalian GFRa4, a divergent member of the GFRa family of coreceptors for GDNF family ligands, is a receptor for the neurotrophic factor persephin
Masure, S., Cik, M., Hoefnagel, E., Nosrat, C. A., van Der Linden, I., Scott, R., Van Gompel, P., Lesage, A. S., Verhasselt, P., Ibanez, C. F., and Gordon, R. D. (2000) J. Biol. Chem. 275, 39427-39434 [PDF]
Distinct structure elements in GDNF mediate binding to GFR alpha 1 and activation of the GFR alpha 1-c-Ret receptor complex
Eketjall, S., Fainzilber, M., Murray-Rust, J., and Ibanez, C. F. (1999) EMBO J. 18, 5901-5910. [PDF]
Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells
Trupp, M., Scott, R., Whittemore, S. R., and Ibanez, C. F. (1999) J. Biol. Chem. 274, 20885-20894 [PDF]
Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase
Trupp, M., Raynoschek, C., Belluardo, N., and Ibanez, C. F. (1998) Mol. Cell. Neurosci. 11, 47-63 [PDF]
Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS
Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. F. (1997) J. Neurosci. 17, 3554-3567 [PDF]
Functional receptor for glial cell line-derived neurotrophic factor encoded by the c-ret proto-oncogene product
Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C. F. (1996) Nature 381, 785-789 [PDF]
GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
Arenas, E., Trupp, M., Akerud, P., and Ibanez, C. F. (1995) Neuron 15, 1465-1473 [PDF]
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons
Trupp, M., Ryden, M., Jornvall, H., Timmusk, T., Funakoshi, H., Arenas, E., and Ibanez, C. F. (1995) J. Cell Biol. 130, 137-148 [PDF]
Physical and functional interaction between GATA-3 and Smad3 allows TGF-bregulation of GATA target genes
Blokzijl, A., ten Dijke, P., and Ibanez, C. F. (2002) Curr. Biol. 12, 35-45
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The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development Reissmann, E., Jornvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M., Ibanez, C. F. (ca) and Brivanlou, A. H. (2001) Genes & Dev 15, 2010-2022 [PDF]
The orphan receptor serine-threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line
Jornvall, H., Blokzijl, A., ten Dijke, P., and Ibanez, C. F. (2001) J. Biol. Chem. 276, 5140-5146. [PDF]
A novel type I serine-threonine kinase receptor predominantly expressed in the adult central nervous system
Ryden, R., Imamura, T., Jornvall, H., Neveu, I., Trupp, M., Belluardo, N., Okadome, T., ten Dijke, P., and Ibanez, C. F. (1996) J. Biol. Chem. 271, 30603-30609 [PDF]
Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4 Belluardo, N., Westerblad, H., Mudo, G., Casabona, A., Bruton, J., Caniglia, G., Pastoris, O., Grassi, F., and Ibanez, C. F. (2001) Mol. Cell. Neurosci. 18, 56-67 [PDF]
Role of BDNF in target invasion in the gustatory system Ringstedt, T., Ibanez, C. F., and Nosrat, C. (1999) J. Neurosci. 19, 3507-3518 [PDF]
Neurotrophin-7 – a novel member of the neurotrophin family from the zebrafish
Nilsson, A. S., Fainzilber, M., Falck, P., and Ibanez, C. F. (1998) FEBS Lett. 424, 285-290 [PDF]
BDNF regulates reelin expression and cajal-retzius cell development in the cerebral cortex
Ringstedt, T., Linnarsson, S., Wagner, J., Lendahl, U., Kokaia, Z., Arenas, E., Ernfors, P., and Ibanez, C. F. (1998) Neuron 21, 305-315 [PDF]
Targeted expression of a multifunctional chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons
Funakoshi, H., Risling, M., Carlstedt, T., Lendahl, U., Timmusk, T., Metsis, M., Yamamoto, Y., and Ibanez, C. F. (1998) Proc.Nat. Acad. Sci. USA95, 5269-5274 [PDF]
Engineering of the heparin-binding domain of neurotrophin-6 onto nerve growth factor Ilag, L.L., Sofie, N. and Ibanez, C.F. (1997). Manuscript. [PDF].
Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system
Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P., and Ibanez, C. F. (1997) Development 124, 2603-2613 [PDF]
A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in NGF
Ryden, M. and Ibanez, C.F. (1997) J. Biol. Chem., 272, 33085-33091 [PDF]
Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor
Ryden, M., Hempstead, B. and Ibanez, C.F. (1997) J Biol Chem, 272, 16322-16328 [PDF]
NMR structure of the death domain of the p75 neurotrophin receptor
Liepinsh, E., Ilag, L.L., Otting, G. and Ibanez, C.F. (1997) EMBO J., 16, 4999-5005 [PDF]
Binding of neurotrophin-3 to p75LNGFR, TrkA and TrkB mediated by a single functional epitope distinct from that recognized by TrkC
Ryden, M. and Ibanez, C.F. (1996) J Biol Chem, 271, 5623-5637 [PDF]
Expression of mRNA for the neurotrophin receptor trkc in neuroblastomas with favourable tumour stage and good prognosis
Ryden, M., Sehgal, R., Dominici, C., Schilling, F. H., Ibanez, C. F., and Kogner, P. (1996) British Journal of Cancer 74, 773-779. [PubMed]
Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons
Funakoshi, H., Belluardo, N., Arenas, E., Yamamoto, Y., Casabona, A., Persson, H., and Ibanez, C. F. (1995) Science 268, 1495-1499. [PDF]
Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling
Ryden, M., Murray-Rust, J., Glass, D., Ilag, L.L., Trupp, M., Yancopoulos, G.D., McDonald, N.Q. and Ibanez, C.F. (1995) EMBO J., 14, 1979-1990. [PDF]
Pan-neurotrophin 1: A genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo
Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N., Ryan, T., Acheson, A., Lindsay, R., Persson, H., Yancopoulos, G.D., DiStefano, P. and Ibanez, C.F. (1995) Proc. Natl. Acad. Sci. USA, 92, 607-611 [PDF]
Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule
Friedman, W. J., Black, I. B., Persson, H., and Ibanez, C. F. (1995) Eur. J. Neurosci. 7, 656-662. [PubMed]
Role of variable b-hairpin loop in determining biological specificities in neurotrophin family
Ilag, L.L., Lonnerberg, P., Persson, H. and Ibanez, C.F. (1994) J. Biol. Chem, 269, 19941-19946. [PDF]
Novel, testis-specific mRNA transcripts encoding N-terminally truncated choline acetyltransferase Lonnerberg, P., and Ibanez, C. F. (1999) Mol. Reprod. Dev. 53, 274-281 [PDF]
Cell type-specific regulation of the choline acetyltransferase gene: Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences
Lonnerberg, P., Schoenherr, C. J., Anderson, D. J., and Ibanez, C. F. (1996)
J. Biol. Chem. 271, 33358-33365 [PDF]
Regulatory region in choline acetyltransferase gene directs developmental and tissue specific expression in transgenic mice
Lonnerberg, P., Lendhal, U., Funakoshi, H., Arhlund-Richter, L., Persson, H., and Ibanez, C. F. (1995) Proc. Natl. Acad. Sci. USA 92, 4046-4050 [PDF]
