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PKC-mediated RhoGDI interaction with p75NTR JUX domain



Growth Factor Receptor Signaling and Biology in Nervous System Development and Metabolic Regulation

With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:

  • p75 neurotrophin receptor and neurotrophin family ligands
  • GFRa1, Ret and NCAM receptors and GDNF family ligands
  • TGF-b superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs

Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.

Current topics of investigation include: