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PKC-mediated RhoGDI interaction with p75NTR JUX domain


RhoGDI phosphorylation by PKC promotes its interaction with death receptor p75 NTR to gate axon growth and neuron survival

Ajeena Ramanujan , Zhen Li, Yanchen Ma, Zhi Lin & Carlos F. Ibáñez (2024)
EMBO Reports doi.org/10.1038/s44319-024-00064-2

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Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization

Chenju Yi1, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez (2020)
The EMBO Journal (2020) e104450

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Cell Death and Disease, doi:10.1038/s41419-019-1970-x

MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating  granule layer/white matter boundary

Diana Fernández-Suárez, Favio A. Krapacher, Annika Andersson, Carlos F. Ibáñez and Lilian Kisiswa (2019)
Cell Death and Disease (2019)10:732

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The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation

Lik-Wei Wong, Jason Y. Tann, Carlos F. Ibanez, and Sajikumar Sreedharan (2019)
J. Neurosci. 2019 • 39(28):5452–5465

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Abnormal TDP‐43 function impairs activity‐dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing

Jason Y Tann, Lik‐Wei Wong, Sreedharan Sajikumar, and Carlos F. Ibáñez (2019)
The EMBO Journal (2019) 10.15252/embj.2018100989

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A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth

Eddy T. H. Goh, Zhi Lin, Bo Young Ahn, Vanessa Lopes-Rodrigues, Ngoc Ha Dang, Shuhailah Salim, Bryan Berger, Brian Dymock, Donna L. Senger and Carlos F. Ibáñez (2018)
Cell Chemical Biology (2018), 25, 1485–1494

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RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival

Lilian Kisiswa, Diana Fernandez-Suarez, Maria Christina Sergaki and Carlos F. Ibáñez (2018)
Cell Reports Volume 24, Issue 4, p1013–1024, 24 July 2018

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Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS

Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim and Carlos F. Ibáñez (2016)
J Neurosci 2016, 36, 5587
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Structural basis of death domain signaling in the  p75 neurotrophin receptor

Zhi Lin, Jason Y. Tann, Eddy T. H. Goh, Claire Kelly, Kim Buay Lim, Jianfang Gao and Carlos F. Ibáñez (2015)
eLife 2015;10.7554/eLife.11692
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Neuron-type-specific signaling by the p75NTR death receptor regulated by differential proteolytic cleavage
Annalisa Vicario, Lilian Kisiswa, Jason Y. Tann, Claire E. Kelly and Carlos F. Ibanez (2015)
J. Cell Sci. 2015, 128, 1507-1517
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Genetic Dissection of Neurotrophin Signaling through the p75 Neu
Genetic dissection of neurotrophin signaling through the p75 neurotrophin  receptor
Charalampopoulos, I, Vicario, A, Pediaditakis, I ,Gravanis, A, Simi, A and Ibanez, CF  (2012)
Cell Reports, 10.1016/j.celrep.2012.11.009
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p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity
Ibanez, C.F. and Simi, A. (2012)
Trends Neurosci., 35, 431–440
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Articles on Neurotrophins and their receptors

Ligand-independent signaling by disulfide- crosslinked dimers of the p75 neurotrophin receptor
Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Reversi, A., Klos-Applequist, J., Karaca, E., Simi, A., Spuch, C., Choi, S., Friedman, W.J., Ericson, J., Schiavo, G., Carter, B.D. and Ibanez, C.F. (2009)
J. Cell Sci, 122, 3351-3357
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Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers
Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Simi, A., Karaca, E., Reversi, A., Choi, S., Bothwell, M., Mingarro, I., Friedman, W.J., Schiavo, G., Bastiaens, P.I.H., Verveer, P.J., Carter, B.D. and Ibanez, C.F. (2009)
Neuron, 62, 72-83
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Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
Vilar, V. Murillo-Carretero, M., Mira, H., Magnusson, K., Besset, V. and Ibanez, C.F. (2006)
EMBO J., 25, 1219-1230
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Jekyll-Hyde neurotrophins: the story of proNGF
Ibanez, C.F. (2002)
Trends Neurosci, 25, 284-286
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Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
Belluardo, N., Westerblad, H., Mudo, G., Casabona, A., Bruton, J., Caniglia, G., Pastoris, O., Grassi, F., and Ibanez, C. F. (2001)
Mol. Cell. Neurosci. 18, 56-67 [PDF]

Role of BDNF in target invasion in the gustatory system
Ringstedt, T., Ibanez, C. F., and Nosrat, C. (1999)
J. Neurosci. 19, 3507-3518 [PDF]

Neurotrophin-7 – a novel member of the neurotrophin family from the zebrafish
Nilsson, A. S., Fainzilber, M., Falck, P., and Ibanez, C. F. (1998)
FEBS Lett. 424, 285-290 [PDF]

BDNF regulates reelin expression and cajal-retzius cell development in the cerebral cortex
Ringstedt, T., Linnarsson, S., Wagner, J., Lendahl, U., Kokaia, Z., Arenas, E., Ernfors, P., and Ibanez, C. F. (1998)
Neuron 21, 305-315 [PDF]

Targeted expression of a multifunctional chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons
Funakoshi, H., Risling, M., Carlstedt, T., Lendahl, U., Timmusk, T., Metsis, M., Yamamoto, Y., and Ibanez, C. F. (1998)
Proc.Nat. Acad. Sci. USA95, 5269-5274 [PDF]

Engineering of the heparin-binding domain of neurotrophin-6 onto nerve growth factor
Ilag, L.L., Sofie, N. and Ibanez, C.F. (1997).
Manuscript. [PDF].

Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system
Ringstedt, T., Kucera, J., Lendahl, U., Ernfors, P., and Ibanez, C. F. (1997)
Development 124, 2603-2613 [PDF]

A second determinant of binding to the p75 neurotrophin receptor revealed by alanine-scanning mutagenesis of a conserved loop in NGF
Ryden, M. and Ibanez, C.F. (1997)
J. Biol. Chem., 272, 33085-33091 [PDF]

Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor
Ryden, M., Hempstead, B. and Ibanez, C.F. (1997)
J Biol Chem, 272, 16322-16328 [PDF]

NMR structure of the death domain of the p75 neurotrophin receptor
Liepinsh, E., Ilag, L.L., Otting, G. and Ibanez, C.F. (1997)
EMBO J., 16, 4999-5005 [PDF]

Binding of neurotrophin-3 to p75LNGFR, TrkA and TrkB mediated by a single functional epitope distinct from that recognized by TrkC
Ryden, M. and Ibanez, C.F. (1996)
J Biol Chem, 271, 5623-5637 [PDF]

Expression of mRNA for the neurotrophin receptor trkc in neuroblastomas with favourable tumour stage and good prognosis
Ryden, M., Sehgal, R., Dominici, C., Schilling, F. H., Ibanez, C. F., and Kogner, P. (1996)
British Journal of Cancer 74, 773-779. [PubMed]

Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons
Funakoshi, H., Belluardo, N., Arenas, E., Yamamoto, Y., Casabona, A., Persson, H., and Ibanez, C. F. (1995)
Science 268, 1495-1499. [PDF]

Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling
Ryden, M., Murray-Rust, J., Glass, D., Ilag, L.L., Trupp, M., Yancopoulos, G.D., McDonald, N.Q. and Ibanez, C.F. (1995)
EMBO J., 14, 1979-1990. [PDF]

Pan-neurotrophin 1: A genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo
Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N., Ryan, T., Acheson, A., Lindsay, R., Persson, H., Yancopoulos, G.D., DiStefano, P. and Ibanez, C.F. (1995)
Proc. Natl. Acad. Sci. USA, 92, 607-611 [PDF]

Synergistic trophic actions on rat basal forebrain neurons revealed by a synthetic NGF/BDNF chimaeric molecule
Friedman, W. J., Black, I. B., Persson, H., and Ibanez, C. F. (1995)
Eur. J. Neurosci. 7, 656-662. [PubMed]

Role of variable b-hairpin loop in determining biological specificities in neurotrophin family
Ilag, L.L., Lonnerberg, P., Persson, H. and Ibanez, C.F. (1994)
J. Biol. Chem, 269, 19941-19946. [PDF]