“Neurotrophic signalling by GDNF and its receptors”
2 June, 1998
External examiner:
Michael E. Greenberg
Harvard Medical School
Cambridge, USA
This thesis is based on the following papers:
I. Trupp, M., Ryden, M., Jornvall, H., Timmusk, T., Funakoshi, H., Arenas, E., and Ibanez, C. F. (1995). Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell. Biol. 130, 137-148 [PDF]
II. Arenas, E., Trupp, M., Akerud, P., and Ibanez, C. F. (1995). GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo. Neuron 15, 1465-1473 [PDF]
III. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B. A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumae, U., Sariola, H., Saarma, M., and Ibanez, C. F. (1996). Functional receptor for glial cell line-derived neurotrophic factor encoded by the c-ret proto-oncogene product. Nature 381, 785-789 [PDF]
IV. Trupp, M., Belluardo, N., Funakoshi, H., and Ibanez, C. F. (1997). Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17, 3554-3567 [PDF]
V. Trupp, M., Raynoschek, C., Belluardo, N., and Ibanez, C. F. (1998). Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Mol. Cell. Neurosci. 11, 47-63 [PDF]
VI. Trupp, M., Scott, R., Whittemore, S. R., and Ibanez, C. F. (1998). Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells. Manuscript. Later published in 1999, J. Biol. Chem. 274, 20885-20894 [PDF]
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