“Functional and bioinformatical studies of the TGF-b superfamily: Identification and characterization of ALK7”
23 November, 2001
External examiner:
Urban Lendahl
Karolinska Institute
Stockholm, Sweden
This thesis is based on the following papers:
I. Ryden, M., Imamura, T., Jornvall, H., Belluardo, N., Neveu, I., Trupp, M., Okadome, T., ten Dijke, P., Ibanez, C.F. (1996) A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. J. Biol. Chem. 271, 30603-30609. [PDF]
II. Jornvall, H., Blokzijl, A., ten Dijke, P., Ibanez, C.F. (2001) The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line. J. Biol. Chem. 276, 5140-5146. [PDF]
III. Reissmann, E., Jornvall, H., Blokzijl, A., Andersson, O., Chang, C., Minchiotti, G., Persico, M.G., Ibanez, C.F., Brivanlou, A.H. (2001) The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by nodal proteins during vertebrate development. Genes & Dev. 15, 2010-2022. [PDF]
IV. Jornvall, H., Ibanez, C.F. (2001) Targeted deletion of the receptor serine/threonine kinase ALK7 in mice. Manuscript. Later published in Mol. Cell. Biol. 24, 9383-9389. [PDF]
V. Jornvall, H. (1999) Motifer, a search tool for finding amino acid sequence patterns from nucleotide sequence databases. FEBS Lett. 456, 85-88. [PDF]
VI. Jornvall, H., Eketjall, S., Gustavsson, J., Kobayashi, S., Lonnerberg, P., Ibanez, C.F. (2001) Identification of two new members of the TGFb ligand superfamily and a new member of the GFRa receptor family using a bioinformatics tool. Manuscript. Later published in 2004: Cell Mol Life Sci61, 488-496. [PDF]
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