“Signal transduction mechanisms mediated by the GDNF family of ligands and their receptors”
8 November, 2002
External examiner:
Marc Billaud
Universite Claude Bernard Lyon 1
Lyon, France
This thesis is based on the following papers:
I. Scott, R. P. and Ibanez, C. F. (2001) Determinants of ligand binding specificity in the GDNF family receptor alphas (GFRas). J. Biol. Chem.276, 1450-1458. [PDF]
II. Scott, R. P., Cederlund, E., Bergmann and Ibanez, C. F. (2002) Structural characterization of GFRas: Identification of ligand binding epitopes, and mapping of disulfide bridges and glycosylation sites. Manuscript. [PDF]
III. Trupp, M.*, Scott, R. P.*, Whittemore, S. R., and Ibanez, C. F. (1999) Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells. J. Biol. Chem. 274, 20885-20894. *Shared first authorship. [PDF]
IV. Besset, V., Scott, R. P. and Ibanez, C. F. (2000). Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase. J. Biol. Chem. 275, 39159-39166. [PDF]
V. Scott, R.P., Eketjall, S., Aineskog, H. and Ibanez, C.F. (2002) Distinct signaling mechanisms by isoforms of the Ret kinase receptor are mediated through differential interaction with Cbl and CrkL. Manuscript. Later published in 2005: J. Biol. Chem.280, 13442-13449. [PDF]
VI. Scott, R. P., Murray-Rust, J., McDonald, N. and Ibanez, C. F. (2002) Production, purification, crystallization of the kinase domain of c-Ret and its oncogenic variants. Manuscript.
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