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PKC-mediated RhoGDI interaction with p75NTR JUX domain


Maurice Perrinjaquet

“Control of neuronal survival, migration and outgrowth by GDNF and its receptors”
16 December, 2010

Abstract from KI website

External examiner:
Rosalind Segal
Departments of Neurobiology, Cancer Biology and Pediatric Oncology
Harvard Medical School and Dana-Farber Cancer Institute
Boston, MA, USA

This thesis is based on the following papers:

I. Perrinjaquet, M., Vilar, M. and Ibanez, C.F. (2010) Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. J. Biol. Chem. 285, 31867-31875. [PDF]

II. Perrinjaquet, M., Sjostrand, D., Moliner, A., Zechel, S., Lambelle, F., Maina, F. and Ibanez, C.F. (2010). Met signaling in GABAergic neurons of the medial ganglionic eminence restricts GDNF activities in cells expressing GFRa1 and a novel transmembrane receptor. Manuscript. Later published in 2011: J. Cell Sci., 124, 2797-2805. [PDF]

III. Kjaer, S., Kurokawa, K., Perrinjaquet, M., Abrescia, C., and Ibanez, C.F. (2006) Self-association of the transmembrane domain of RET underlines oncogenic activation by MEN2A mutattions. Oncogene 25, 7086-7095. [PDF]

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